Most mitochondrial diseases are caused by a change in mitochondrial DNA. This is DNA found in mitochondria that makes some of the proteins we need to make ATP. So if this DNA is damged then it causes a decrease in the amount of ATP we get for our cells to use as energy.
My work is trying to find away of changing the DNA expression to try and treat the mitochondrial diseases. So this will mean that only “good” proteins are made. This is a nice approach of treating them as it shouldnt have any side effects as only the rubbish proteins are stopped from being made, and everything else is left alone.